DEPARTMENT OF BIOPHARMACY

Biopharmacy is a relatively new discipline that deals with the behaviour of complex pharmaceutical forms, drug releasing systems and active compounds in the human body. To master the subject one must know the basics of pharmaceutical technology as well as biology, physiology, clinicopathology and pharmacology. During the semester students learn pharmacokinetics and also the different rules concerning the liberation, absorption, distribution, metabolism and elimination (excretion) of active compounds (pharmacons) in a living organism, and further the possibilities to enhance and decrease these processes, with basic kinetics.

This department also gives Pharmaceutical care courses. Pharmaceutical care is the responsible provision of drug therapy for the purpose of achieving definite outcomes that improve a patient’s quality of life. Pharmaceutical care involves the process through which a pharmacist co-operates with a patient and other professionals in designing, implementing, and monitoring a therapeutic plan that will produce specific therapeutic outcomes for the patient.

Classes taught:

·         Biopharmacy

·         Pharmaceutical Care

·         Pharmaceutical and Bioanalytical Chemistry

Scientific profile, research interest:

The Department of Biopharmacy works on projects on the development of several new drugs such as luteinizing hormone-releasing hormone (LH-RH) analogs, somatostatin analogs, bombesin/gastrin-releasing peptide (GRP) antagonists, targeted cytotoxic peptide analogs and growth hormone-releasing hormone (GH-RH) antagonists for the treatment of human cancers such as breast cancer, prostate cancer, ovarian carcinoma, pancreatic cancer, lunger cancer, colon cancer and the other tumours. Our research work demonstrated the presence of receptors and the expression of their mRNA for bombesin/GRP, LH-RH, somatostatin and GH-RH in various human cancers as new molecular targets, which is a very exciting development in cancer research, as it may lead to new methods for the diagnosis and treatment of such malignancies. We also investigate the mechanism of action of peptide analogs and targeted cytotoxic peptide conjugates on human cancer models and our team studies the down regulation, subcellular distribution, internalization and translocation of peptide and growth factor receptors in human cancers.

Cooperation partners:

Universities:

·         University of Miami Miller School of Medicine and Veterans Affairs Medical Center, (Miami, FL, USA)

·         University of Tennessee College of Pharmacy (Memphis, TN, USA)

·         East Tennessee State University Bill Gatton College of Pharmacy (Johnson City, TN, USA)

·         Chapman University School of Pharmacy (Irvine, CA, USA)

·         Ferris State University College of Pharmacy (Grand Rapids, MI, USA)

·         University of Szeged Faculty of Medicine Department of Internal Medicine and Endocrinology (Szeged, Hungary)

·         Eötvös L. University, MTA-ELTE Research Group of Peptide Chemistry, Hungarian Academy of Sciences (Budapest, Hungary)

Organisations:

 

Activities in international and Hungarian research and educational grants:

·         OTKA  K 81596 (2009-2014)

·         OTKA  K 104045 (2012-2015)

·         TÁMOP 4.2.2.A-11/1/KONV-2012-0025 /Molecular Oncology (2012-2015)

·         TÁMOP-6.2.5.A-12/1 (2013-2015)

·         TÁMOP-4.1.1.C-13/1/KONV-2014-0001 (2014-2015)

·         Magyary Zoltan postdoctoral program

·         Eotvos postdoctoral program

·         Hungarian Society of Oncology

·         Campus Hungary Fellowships

·         University of Miami/VA Medical Center/Weeks Foundation (USA)