Conference on Therapeutical Purposes Research and Development II

23-24 September 2021

 

Debrecen online conference, Hungary

 

 



 

REGISTRATION

 



 

PROGRAM OVERVIEW

 



 

 


 Head of the Conference:

Prof. Dr. Zoltán Szilvássy


Secretary of Conference:

Prof. Dr. Ildikó Bácskay


Conference Scientific Committee:

Dr. Pálma Fehér

Dr. Ferenc Fenyvesi

Dr. Béla Juhász

Dr. Rita Kiss

Dr. Zoltán Ujhelyi

Dr. Judit Váradi


 

 

 

 

Welcome Remark

 

Dear Friends and Colleagues,

Welcome to the 2nd online Conference on Therapeutical Purposes Research and Development. Taking place on September 23-24, 2021 in Debrecen, Hungary. The Conference aims to summarize the results of the project called R&D for Therapeutical Purposes and gives opportunity for international partners to introduce their researches. Young scientists were also highlighted to present their work. We invite all participants to join our online conference where we can share the experiences and discuss our developments.

Sincerely Yours,

The Organizing Commitee

 

 


 

 

Scientific Program

 

23rd September, 2021 (Thursday)

  1. Session (10 min.lecture, 5 min.discussion)

Chair: Prof. Dr. Ildikó Bácskay, Dr. Béla Juhász

13:00-13:15    Strategies for the design of protein kinase CK2 inhibitors 

Marc Le Borgne1, Ildikó Bácskay2,3, Pálma Fehér2

1Faculty of Pharmacy, University of Claude Bernard Lyon, 2Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, 3Institute of Healthcare Industry, University of Debrecen

 

13:15-13:30    Synthesis of indenoindoles and their evaluation as bioactive molecules

Christelle Marminon, Zouhair Bouaziz

1Faculty of Pharmacy, University of Claude Bernard Lyon

 

13:30-13:45   The deleterious effects of new insecticides on the neurophysiology and the behaviour of the honey bee

Claude Collet

French National Institute for Agriculture, Food, and Environment (INRAE), Avignon, France

 

13:45-14:00    Theranostics on demand

Maria Clara Goncalves

Department of Engeneering Chemistry, University of Tecnico Lisboa

 

14:00-14:15    The role of astaxanthin in the evolution of multicellular organisms

 

László Csernoch, Mónika Gönczi, Zoltán Singlár, Beatrix Dienes, Péter Szentesi, Mónika Sztretye

Department of Physiology, Faculty of Medicine, University of Debrecen

 

 

14:15-14:30   Phytochemical Screening, Antioxidant Activity and Extraction of Active Compound from Different Medicinal Plant Species Growing in the Bihor-Hajdú Bihar Area

Tünde Jurca1, Annamaria Pallag1, Eleonora Marian1, Laura Vicas1, Mariana Muresan2, Diana Gavra1:

1Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 2Department of Preclinical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea

 

14:30-14:45   Current Perspectives in the Study of Medicinal Plant Species Growing in The Bihor-Hajdú Bihar Area

Annamaria Pallag1, Tünde Jurca1, Eleonora Marian1, Laura Vicas1, Mariana Muresan2, Cristina Burlou Nagy1

1Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 2Department of Preclinical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea

 

  1. Session (10 min.lecture, 5 min.discussion)

Chair: Dr. Pálma Fehér, Dr. Zoltán Ujhelyi

 

15:00-15:15   Preformulation studies and bioavailability enhancement of curcumin with beta-cyclodextrin polymers

Ferenc Fenyvesi1, Ádám Haimhoffer1, Eleftheria Dossi2, László Jicsinszky3, Éva Fenyvesi4, Ildikó Bácskay1,5

1Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, 2Cranfield Defence and Security, Cranfield University, 3Department of Drug Science and Technology, University of Turin, 4Cyclolab Cyclodextrin R & D Laboratory Ltd, 5Institute of Healthcare Industry, University of Debrecen

                                                                                                        

15:15-15:30   Pharmacological and bioavailability background of the development of formulations containing Prunus cerassus extract

1Váradi Judit, Ferenc Fenyvesi1, Gábor Vasvári1, Judit Homoki2, Judit Remenyik2

1Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, 2Institute of Food and Feed Technology, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen

 

15:30-15:45   Development of oral peptide delivery systems, a complicated puzzle of possibilities

Zoltán Ujhelyi1, Dóra Kósa1, Ágota Pető1, Miklós Vecsernyés1

1Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen

 

15:45-16:00   Curcumin loaded gastroretentive, solid self-emulsifying systems: design and development

Gábor Vasvári1, Orsolya Csendes1, László Horváth2, Ádám Haimhoffer1, Ildikó Bácskay1,3, Béla Juhász4

1 Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, 2 Department of Pharmaceutical Surveillance and Economics, Faculty of Pharmacy, University of Debrecen, 3 Institute of Healthcare Industry, University of Debrecen, 4 Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen

 

16:00-16:15   Complexation of curcumin with beta-cyclodextrins derivatives:
solubility, dissolution and transmembrane permeability on Caco-2
monolayers

Ágnes Rusznyák1, Gábor Vasvári1, Judit Váradi1, Ferenc Fenyvesi1, Ildikó Bácskay1,2,MiklósVecsernyés1
1Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, 2Institute of Healthcare Industry, University of Debrecen

 

16:15-16:30   Formulation of self-emulsifying system containing curcumin for external dosage form.

Liza Józsa1, Pálma Fehér1, Ildikó Bácskay1,2

1Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, 2Institute of Healthcare Industry, University of Debrecen

 

16:30-16:45   Formulation of nanoparticles containing Casein kinase 2 inhibitor for the therapy of glioblastoma.

Pálma Fehér1, Marc Le Borgne2, Florent Perret3, Christelle Marminon2,Ujhelyi Zoltán1, Ágota Pető1, Liza Józsa1, Ildikó Bácskay1,4

1Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, 2Faculty of Pharmacy, University of Claude Bernard Lyon, Chemistry Department, University of Claude Bernard Lyon, 4Institute of Healthcare Industry, University of Debrecen

 

16:45-17:00   Development and evaluation of topical formulation Containing Rosa damascena lyophilized extract

Diana Gavra1, Pálma Fehér2, Liza Józsa2,Pető Ágota2 Annamária Pallag1, Ildikó Bácskay2,3, Tünde Jurca1

1Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 2Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, 3Institute of Healthcare Industry, University of Debrecen

 

 

24th September, 2021 (Friday)

  1. Session (10 min.lecture, 5 min.discussion)

 

Chair: Dr. Priksz Dániel, Dr. Ferenc Fenyvesi

 

9:00-9:15       Strategies preventing doxorubicin induced cardiomyopathy in a rat model

Mária Lódi1,2, Viktor Bánhegyi1, Dániel Priksz3, Gábor Áron Fülöp1, Beáta Bódi1, Alexandra Gyöngyösi4, Lilla Nagy5, Árpád Kovács6,Attila Béla Kertész6, Anita Árokszállási7, Judit Kocsis7, Nazha Hamdani8,9, Miklós Fagyas1, István Édes6, Zoltán Csanádi6, István Czuriga6, Zoltán Kisvárday10, Béla Juhász3, István Lekli4, Péter Bai5, Attila Tóth1, Zoltán Papp1 and Dániel Czuriga1Division of Clinical Physiology, Department of Cardiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. 2Department of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Medical Faculty, Bochum, Germany 3Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen, Hungary 4Department of Pharmacology, Faculty of Pharmacy, University of Debrecen, Debrecen, Hungary. 5MTA-DE Lendület Laboratory of Cellular Metabolism, Debrecen, Hungary 6Division of Cardiology, Department of Cardiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. 7Department of Oncology, Faculty of Medicine, University of Debrecen,Debrecen, Hungary, 8 Department of Molecular and Experimental Cardiology,Ruhr University Bochum, Bochum, Germany. 9Department of Cardiology, St.Josef-Hospital, Ruhr University Bochum, Bochum, Germany. 10Department of Anatomy, Histology and Embryology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

 

 

9:15-9:30       Difference in self- and physician reported type 2 diabetic patient adherence as a function of hba1c and psychometric measures

László Maroda1, Miklós Zrínyi1, Tamás Köbling1, Zita Váradi1, Melinda Nyisztor1, Éva Katona1, Dénes Páll1

Department of Internal Medicine, Faculty of Medicine, University of Debrecen

 

9:30-9:45        Predictors of dietary self-efficacy in high hba1c type 2 diabetic patients.

Tamás Köbling1, László Maroda1, Zita Váradi1, Melinda Nyisztor1, Éva Katona1, Dénes Páll1, Miklós Zrínyi1

1Department of Internal Medicine, Faculty of Medicine, University of Debrecen

 

9:45-10:00     Discriminating low to high hba1c type 2 diabetic patients using psychosocial determinants including therapeutic adherence measures.

Zita Váradi1, Tamás Köbling1, László Maroda1, Melinda Nyisztor1, Éva Katona1, Dénes Páll1, Miklós Zrínyi1

1Department of Internal Medicine, Faculty of Medicine, University of Debrecen

 

10:00-10:15   Carotenoids, as biological mediators responsible for enhanced skeletal muscle function

Zoltán Singlár, Péter Szentesi, János Fodor, Mónika Gönczi, Zsolt Ráduly, László Csernoch, Mónika Sztretye

 

Department of Physiology, Faculty of Medicine, University of Debrecen

 

10:15-10:30    Assesing the potentials of nutraceuticals in mice

Mónika Sztretye, Zoltán Singlár, János Fodor, Péter Szentesi, László Szabó, Beatrix Dienes, Andrea Telek, Balázs Pál, László Csernoch

Department of Physiology, Faculty of Medicine, University of Debrecen

 

10:30-10:45   Evaluation of antimicrobial activity and in vitro studies on cell cultures of different herbal extracts harvested from the bihor-hajdú bihar county area

Mariana Muresan1, Annamaria Pallag 2, Tünde Jurca 2, Otilia Micle 1, Eleonora Marian2, Laura Vicas2, Simona Clichici3, Adriana Filip3

1Department of Preclinical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 2Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 3Department of Physiology, "Iuliu Haţieganu" University of Medicine and Pharmacy Cluj-Napoca

 

10:45-11:00   The role of HEGC (Hyperinsulinemic Euglycemic Glucose Clamp) in prediabetes

Dana Romanescu1, Mihaela Popoviciu1, Ioan Magyar2, Rita Kiss3, Anna Szilágyi3, Barbara Takács3, Réka Szekeres3, Sándor Somodi4, Péter Kovács4, Zoltán Szabó5, József Németh3, Zoltán Szilvássy3, Béla Juhász3

1Department of Preclinical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 2Department of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea 3Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, 4Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 5Department of Emergency Medicine, Faculty of Medicine, University of Debrecen

 

11:00-11:15   Equisetum Arvense L. (Horsetail) modulates insulin sensitivity in streptozotocin induced diabetic rats

Rita Kiss1, Andrea Badale1, Csaba Hegedűs1, Mariana Muresan2, Mariann Bombicz1, Balázs Varga1, Anna Szilágyi1, Dávid Sinka3, Ildikó Bácskay3, Mihaela Popoviciu4, Ioan Magyar2, Mária Magdolna Szarvas5, Erzsébet Szőllősi5, József Németh1, Zoltán Szilvássy1, Annamaria Pallag6

1Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, 2Department of Preclinical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 3Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, 4Department of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 5Faculty of Agricultural and Food Sciences and Environmental Sciences, Institute of Food Technology, University of Debrecen, 6Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea

 

  1. Session (10 min.lecture, 5 min.discussion)

 

Chair: Dr. Rita Kiss, Dr. Judit Váradi

 

11:30-11:45   Improved survival and retinal function of aging ZDF rats in long-term, uncontrolled diabetes by BGP-15 treatment

Barbara Takács1, Zita Wachal1, Anna Szilágyi1, Adrienn Mónika Szabó1, Dániel Priksz1, Mariann Bombicz1, Judit Szilvássy2, Béla Juhász1, Balázs Varga1, Zoltán Szilvássy1

1Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, 2Department of Oto-Rhino-Laryngology and Head-Neck Surgery, Faculty of Medicine, University of Debrecen

 

11:45-12:00   The therapeutic properties of the main components of Ayahuasca in retinal ischaemia-reperfusion injury

Anna Szilágyi1, Barbara Takács1, Réka Szekeres1, Béla Juhász1, Csaba Hegedűs1, Ede Frecska2, Attila Kovács2, Zoltán Szilvássy1, Balázs Varga1

1Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, 2Department of Psychiatry, Faculty of Medicine, University of Debrecen

 

12:00-12:15   Prunus Cerasus-Extract Improves Hypercholesterinaemia-Induced Cardial Dysfunction in Aging Rabbit Model

Réka Szekeres1, Rita Kiss1, Dániel Priksz1, Mariann Bombicz1, Balázs Varga1, Anna Szilagyi1, Barbara Takács1, Judit Remenyik2, Georgina Pesti-Asbóth2, Rudolf Gesztelyi1, Tamás Erdei1, Gábor Viczjan1, Ignác Ovari1, Zoltan Szilvássy1, Béla Juhász1

1Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, 2Faculty of Agricultural and Food Sciences and Environmental Sciences, Institute of Food Technology, University of Debrecen

 

12:15-12:30   Negative inotropic effect of BGP-15 on the human right atrial myocardium

Nóra Lampé1, Dániel Priksz1, Tamás Erdei1, Mariann Bombicz1, Rita Kiss1, Balázs Varga1, Judit Zsuga2, Tamás Szerafin3, Zoltán Csanádi3, György Balla4, József Balla5, Zoltán Szilvássy1, Rudolf Gesztelyi1, Béla Juhász1

1Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, 2Department of Health Management, Faculty of Public Health, University of Debrecen, 3Department of Cardiology and Cardiac Surgery, Faculty of Medicine, University of Debrecen, 4Department of Paediatrics, Neonatology, Faculty of Medicine, University of Debrecen, 5Department of Internal Medicine, Faculty of Medicine, University of Debrecen

 

12:30-12:45   An interaction between effects of FSCPX (A verified irreversible A1 adenosine receptor antagonist and putative irreversible adenosine-related enzyme inhibitor) and NBTI (an adenosine transport inhibitor) in isolated, paced rat and guinea pig left atria

Ignac Ovari1, Gabor Viczjan1, Tamas Erdei1, Nora Lampe1, Judit Zsuga2, Zoltan Szilvassy1, Bela Juhasz1, Rudolf Gesztelyi1

1Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, 2Department of Health Management, Faculty of Public Health, University of Debrecen

 

12:45-13:00   Kinetic aspects of the effect of FSCPX, a verified irreversible A1 adenosine receptor antagonist and putative irreversible adenosine-related enzyme inhibitor, under ex vivo experimental conditions

Gabor Viczjan1, Ignac Ovari1, Tamas Erdei1, Nora Lampe1, Judit Zsuga2, Zoltan Szilvassy1, Bela Juhasz1, Rudolf Gesztelyi1

1 Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, 2Department of Health Management, Faculty of Public Health, University of Debrecen

 

13:00-13:15    The Impact of Corticosteroid Therapy on Sars-Cov-2 Infection

Ioan Magyar1, Rita Kiss2, Mihai Botea3, Carmen Pantiș3, Lorena Păduraru1, Alexandru Hasan Mădălin1

1Department of Preclinical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 2Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, 3Department of Surgical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea

 

                                                                                                                                       

 

 

 


 

"The research was supported by the Thematic Excellence Programme (TKP2020-IKA-04) of the Ministry for Innovation and Technology in Hungary."

 

 



 

TKP2020-IKA-04

Big Data, Biotechnológia, Energetika, Terápiás célú fejlesztés, Vízzel kapcsolatos kutatások és a négy Lendület kutatócsoport továbbfinanszírozása

 

 

 

 

 

 

 

 

 

Frissítés dátuma: 2021.09.22.


Tisztelt Felhasználó!

 

A Debreceni Egyetem kiemelt fontosságúnak tartja a rendelkezésére bocsátott, illetve birtokába jutott személyes adatok védelmét. Ezúton tájékoztatjuk Önt, hogy a Debreceni Egyetem a 2018. május 25. napjától kötelezően alkalmazandó Általános Adatvédelmi Rendelet alapján felülvizsgálta folyamatait és beépítette a GDPR előírásait az adatkezelési és adatvédelmi tevékenységébe. A felhasználók személyes adatait a Debreceni Egyetem korábban is teljes körültekintéssel kezelte, megfelelve az érvényben lévő adatkezelési szabályozásoknak. A GDPR előírásait követve frissítettük Adatvédelmi Tájékoztatónkat, amelyet az alábbi linkre kattintva olvashat el: Adatkezelési tájékoztató. DE Kancellária VIR Központ

A tájékoztatót megismertem.