Research Directions
The research activities of the department are primarily focused on the design, synthesis, and medicinal chemistry investigation of biologically active compounds. Key areas include carbohydrate and nucleoside chemistry, specifically the research of oligosaccharides, neuraminic acid derivatives, glycomimetics, and nucleoside analogues as well as the development of novel antimicrobial and anticancer drug candidates.
Another important research direction is the study of hydrogen sulfide-donating drug candidates, as well as the modification of glycopeptide antibiotics and other naturally occurring bioactive compounds with the aim of producing novel antiviral and antibacterial agents. The research also extends to the design and synthesis of biologically active cannabinoid derivatives and the biological evaluation of new drug candidate molecules within the framework of national and international collaborations.
Current Research Topics
- Carbohydrate chemistry and synthesis of biologically active oligosaccharides
- Synthesis of antiviral and antibacterial glycopeptide antibiotics
- Preparation of cannabidiol and cannabigerol derivatives
- Synthesis of neuraminic acid derivatives
- Synthesis of anticancer, antiviral, and antiparasitic nucleoside derivatives
- Application of thioclick reactions for the preparation of carbohydrate derivatives
- Development of potential SGLT2 inhibitor agents
- Design and synthesis of lectin inhibitors
- Preparation of O,N-heterocycles from carbohydrate precursors
- Preparation of H2S-donating compounds
Publications
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